After 45 years promoting treatment and a cure for children he calls "my kids," comedian Jerry Lewis announced Monday he is retiring as host of the Labour Day Muscular Dystrophy Association telethon that has become synonymous with his name.

Lewis, 85, issued a statement through the association calling it "time for an all new Telethon era."

"As a Labour of love, I've hosted the annual Telethon since 1966 and I'll be making my final appearance on the show this year by performing my signature song, `You'll Never Walk Alone,"' Lewis said of a shortened six-hour primetime broadcast scheduled for Sept. 4.

Lewis, a Las Vegas resident, has in recent years battled a debilitating back condition, heart issues and the crippling lung disease pulmonary fibrosis. He said he'll continue serving as national Muscular Dystrophy Association chairman, as he's done since the early 1950s.

"I'll never desert MDA and my kids," he said.

Officials with the Tucson, Ariz.-based nonprofit hailed Lewis as one of the world's great humanitarians.

More than $1 billion has been raised during Muscular Dystrophy Association telethons over the years, association spokesman Jim Brown said. And a national network of some 200 hospital-affiliated clinics has opened since Lewis became involved in the telethon.

Lewis' first live Labour Day weekend telethon in 1966 was broadcast by a single New York City television station. It raised more than $1 million in pledges.

The telethon moved from New York to Las Vegas in 1973 and had stints in Los Angeles before returning in 2006 to Las Vegas.

Last year's Jerry Lewis MDA Telethon aired from the South Coast hotel-casino on the Las Vegas Strip and was broadcast by more than 170 stations. It raised almost $59 million to fund research to find a cure for muscular dystrophy and ALS, or Lou Gehrig's disease.

The live telethon usually lasts 21 1/2 hours. Sometimes Lewis sings or tells lighthearted jokes. He introduces guests and other performers like a ringmaster. Sometimes, he turns serious and shares stories of people afflicted by the disease or who are helped by the association. All the while, he urges donors to contribute while a tote board rings up pledge totals.